[FRCMNS0Participant]

In this case, I am sure that MarkupSimplifier is modifying the styles.xml file. Here is the entire sample code used:

using DocumentFormat.OpenXml.Packaging;
using OpenXmlPowerTools;
using System;
using System.Collections.Generic;
using System.IO;
using System.Linq;
using System.Text;

namespace DocxTest
{
    class Program
    {
        static void Main(string[] args)
        {
            try
            {
                File.Copy("PORTA.docx", "PORTA_copy.docx");
                using (var docMaster = WordprocessingDocument.Open("PORTA_copy.docx", true))
                {
                    SimplifyMarkupSettings settings = new SimplifyMarkupSettings
                    {
                        NormalizeXml = true, // Merges Run's in a paragraph with similar formatting

                        // Additional settings if required
                        RemoveBookmarks = true,
                        RemoveComments = true,
                        RemoveGoBackBookmark = true,
                        RemoveWebHidden = true,
                        RemoveContentControls = true,
                        RemoveEndAndFootNotes = true,
                        //RemoveFieldCodes = true,
                        RemoveLastRenderedPageBreak = true,
                        RemovePermissions = true,
                        RemoveProof = true,
                        RemoveRsidInfo = true,
                        RemoveSmartTags = true,
                        RemoveSoftHyphens = true,
                    };

                    MarkupSimplifier.SimplifyMarkup(docMaster, settings);

                    docMaster.Save();
                }

                Console.WriteLine("Done.");
            }
            catch(Exception ex)
            {
                Console.WriteLine("Error: {0}", ex.ToString());
            }
            
            Console.ReadLine();
        }
    }
}

There’s nothing else being done to the document.
Most of the differences are a extra space before closing a tag or reordered attributes.

The major change is right on the beginning of the file, mostly additional namespace declarations.

Here is a WinMerge report with the differences highlighted:
https://drive.google.com/file/d/0B0ZNalzpb4uFRjdndWFidTduME0/view?usp=sharing

[FRCMNS0Participant]

As an addendum, the extra SimplifyMarkupSettings options (everything besides NormalizeXml) doesn’t cause errors, only when NormalizeXml is set this problem occurs.

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